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TFPT
Appears to promote apoptosis in a p53/TP53-independent manner. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Oncoprotein |
| Chromosomal Location of human Ortholog: 19q13.42 |
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Cellular Component:
actin filament; cytoplasm; Ino80 complex; nucleoplasm; nucleus
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Molecular Function:
DNA binding; protein binding; protein kinase binding; protein-containing complex binding
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Biological Process:
apoptotic signaling pathway; chromatin remodeling; DNA recombination; DNA repair; male gonad development; positive regulation of apoptotic process; positive regulation of DNA repair; positive regulation of DNA-templated transcription; positive regulation of telomere maintenance in response to DNA damage; regulation of cell cycle; regulation of chromosome organization; regulation of DNA repair; regulation of DNA replication; regulation of DNA strand elongation; regulation of embryonic development; telomere maintenance
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Reference #:
P0C1Z6
(UniProtKB)
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Alt. Names/Synonyms: amida; amida, partner of the E2A; FB1; INO80 complex subunit F; INO80F; Protein FB1; TCF3 (E2A) fusion partner (in childhood Leukemia); TCF3 fusion partner; TFPT
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Gene Symbols: TFPT
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Molecular weight:
28,278 Da
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Basal Isoelectric point:
5.19
Predict pI for various phosphorylation states
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