TFIP11 Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. Belongs to the TFP11/STIP family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 22q12.1
Cellular Component:  catalytic step 2 spliceosome; cytoplasm; extracellular matrix; nuclear chromosome, telomeric region; nuclear speck; nucleolus; nucleoplasm; spliceosomal complex; U2-type post-mRNA release spliceosomal complex
Molecular Function:  nucleic acid binding; protein binding
Biological Process:  biomineral tissue development; mRNA splicing, via spliceosome; negative regulation of DNA ligase activity; negative regulation of double-strand break repair via nonhomologous end joining; negative regulation of protein binding; negative regulation of protein complex assembly; protection from non-homologous end joining at telomere; RNA processing; spliceosomal complex disassembly
Reference #:  Q9UBB9 (UniProtKB)
Alt. Names/Synonyms: bK445C9.6; FLJ22086; hNtr1; NTR1; Septin and tuftelin-interacting protein 1; sip1/tuftelin interacting protein; Spp382; STIP; STIP-1; TFIP11; TFP11; TIP39; tuftelin interacting protein 11; Tuftelin-interacting protein 11
Gene Symbols: TFIP11
Molecular weight: 96,820 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein