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SRm160
Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. Belongs to the splicing factor SR family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of human Ortholog: 1p36.11 |
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Cellular Component:
catalytic step 2 spliceosome; cytosol; nuclear matrix; nuclear speck; nucleoplasm; nucleus; spliceosomal complex
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Molecular Function:
DNA binding; protein binding
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Biological Process:
localization; mRNA splicing, via spliceosome; regulation of mRNA splicing, via spliceosome; RNA splicing; RNA splicing, via transesterification reactions
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Reference #:
Q8IYB3
(UniProtKB)
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Alt. Names/Synonyms: 160-KD; MGC39488; plenty of prolines 101-like; POP101; Ser/Arg-related nuclear matrix protein; serine and arginine repetitive matrix 1; serine/arginine repetitive matrix 1; Serine/arginine repetitive matrix protein 1; SR-related nuclear matrix protein of 160 kDa; SRM160; SRRM1
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Gene Symbols: SRRM1
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Molecular weight:
102,335 Da
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Basal Isoelectric point:
11.84
Predict pI for various phosphorylation states
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