SRm160 Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. Belongs to the splicing factor SR family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component:  catalytic step 2 spliceosome; cytosol; nuclear matrix; nuclear speck; nucleoplasm; nucleus
Molecular Function:  DNA binding; protein binding
Biological Process:  mRNA 3'-end processing; mRNA export from nucleus; mRNA splicing, via spliceosome; RNA export from nucleus; RNA splicing; RNA splicing, via transesterification reactions
Reference #:  Q8IYB3 (UniProtKB)
Alt. Names/Synonyms: 160-KD; MGC39488; plenty of prolines 101-like; POP101; Ser/Arg-related nuclear matrix protein; serine/arginine repetitive matrix 1; Serine/arginine repetitive matrix protein 1; SR-related nuclear matrix protein of 160 kDa; SRM160; SRRM1
Gene Symbols: SRRM1
Molecular weight: 102,335 Da
Basal Isoelectric point: 11.84  Predict pI for various phosphorylation states
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SRm160

Protein Structure Not Found.


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