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RCC1 iso2
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; GEF; GEF, Ras |
| Chromosomal Location of human Ortholog: 1p35.3 |
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Cellular Component:
chromatin; chromosome; condensed nuclear chromosome; cytoplasm; nucleoplasm; nucleus; protein-containing complex
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Molecular Function:
chromatin binding; guanyl-nucleotide exchange factor activity; histone binding; nucleosomal DNA binding; nucleosome binding; protein binding; protein heterodimerization activity; small GTPase binding; sulfate binding
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Biological Process:
cell division; chromosome segregation; G1/S transition of mitotic cell cycle; mitotic nuclear membrane reassembly; mitotic spindle organization; regulation of mitotic nuclear division; spindle assembly; viral process
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Reference #:
P18754-2
(UniProtKB)
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Alt. Names/Synonyms: Cell cycle regulatory protein; CHC1; chromosome condensation 1; Chromosome condensation protein 1; guanine nucleotide-releasing protein; RCC1; RCC1 iso2; RCC1-I; Regulator of chromosome condensation; regulator of chromosome condensation 1; SNHG3-RCC1; SNHG3-RCC1 readthrough
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Gene Symbols: RCC1
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Molecular weight:
48,146 Da
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Basal Isoelectric point:
8.44
Predict pI for various phosphorylation states
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