GluR4 iso2 Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component:  AMPA glutamate receptor complex; cell junction; dendritic spine; endocytic vesicle membrane; neuronal cell body; plasma membrane; postsynaptic membrane
Molecular Function:  AMPA glutamate receptor activity; amyloid-beta binding; ionotropic glutamate receptor activity
Biological Process:  glutamate receptor signaling pathway; ion transmembrane transport; ionotropic glutamate receptor signaling pathway; regulation of NMDA receptor activity
Reference #:  P48058-2 (UniProtKB)
Alt. Names/Synonyms: AMPA-selective glutamate receptor 4; GluA4; GluR-4; GluR-D; GluR4; GluR4 iso2; GLUR4C; GLURD; glutamate ionotropic receptor AMPA type subunit 4; Glutamate receptor 4; Glutamate receptor ionotropic, AMPA 4; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 4; GRIA4; NEDSGA
Gene Symbols: GRIA4
Molecular weight: 49,146 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
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GluR4 iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein