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SCML2
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. Belongs to the SCM family. Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of human Ortholog: Xp22.13 |
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Cellular Component:
nucleus; PcG protein complex
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Molecular Function:
chromatin binding; histone binding; protein binding
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Biological Process:
anatomical structure morphogenesis; negative regulation of DNA-templated transcription
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Reference #:
Q9UQR0
(UniProtKB)
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Alt. Names/Synonyms: Scm polycomb group protein like 2; SCML2; sex comb on midleg like 2; sex comb on midleg-like 2 (Drosophila); Sex comb on midleg-like protein 2
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Gene Symbols: SCML2
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Molecular weight:
77,257 Da
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Basal Isoelectric point:
8.79
Predict pI for various phosphorylation states
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