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SF3B2
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Note: This description may include information from UniProtKB.
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| Protein type: RNA processing; RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of human Ortholog: 11q13.1 |
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Cellular Component:
catalytic step 2 spliceosome; nuclear speck; nucleoplasm; nucleus; precatalytic spliceosome; spliceosomal complex; U12-type spliceosomal complex; U2 snRNP; U2-type precatalytic spliceosome; U2-type spliceosomal complex
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Molecular Function:
protein binding
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Biological Process:
mRNA processing; mRNA splicing, via spliceosome; RNA splicing; U2-type prespliceosome assembly
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Disease: Craniofacial Microsomia
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Reference #:
Q13435
(UniProtKB)
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Alt. Names/Synonyms: Cus1; pre-mRNA splicing factor SF3b 145 kDa subunit; Pre-mRNA-splicing factor SF3b 145 kDa subunit; SAP 145; SAP145; SF3b1; SF3b145; SF3b150; SF3B2; spliceosome associated protein 145; Spliceosome-associated protein 145; Splicing factor 3B subunit 2; splicing factor 3b, subunit 2, 145kD; splicing factor 3b, subunit 2, 145kDa
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Gene Symbols: SF3B2
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Molecular weight:
100,228 Da
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Basal Isoelectric point:
5.52
Predict pI for various phosphorylation states
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