SF3B2 Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of human Ortholog: 11q13.1
Cellular Component:  catalytic step 2 spliceosome; nuclear speck; nucleoplasm; nucleus; precatalytic spliceosome; spliceosomal complex; U12-type spliceosomal complex; U2 snRNP; U2-type precatalytic spliceosome; U2-type spliceosomal complex
Molecular Function:  protein binding
Biological Process:  mRNA processing; mRNA splicing, via spliceosome; RNA splicing; U2-type prespliceosome assembly
Disease: Craniofacial Microsomia
Reference #:  Q13435 (UniProtKB)
Alt. Names/Synonyms: Cus1; pre-mRNA splicing factor SF3b 145 kDa subunit; Pre-mRNA-splicing factor SF3b 145 kDa subunit; SAP 145; SAP145; SF3b1; SF3b145; SF3b150; SF3B2; spliceosome associated protein 145; Spliceosome-associated protein 145; Splicing factor 3B subunit 2; splicing factor 3b, subunit 2, 145kD; splicing factor 3b, subunit 2, 145kDa
Gene Symbols: SF3B2
Molecular weight: 100,228 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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