CCNT2 iso3 Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). The activity of this complex is regulated by binding with 7SK snRNA. Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II. In addition, enhances MYOD1-dependent transcription through interaction with PKN1. Involved in early embryo development. (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. Belongs to the cyclin family. Cyclin C subfamily. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 1|1 E3
Cellular Component:  cyclin/CDK positive transcription elongation factor complex; cytoplasm; cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  7SK snRNA binding; chromatin binding; cyclin-dependent protein serine/threonine kinase activator activity; cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; protein kinase binding; RNA polymerase binding; transcription coactivator binding
Biological Process:  cell cycle; cell division; early viral transcription; late viral transcription; positive regulation of DNA-templated transcription, elongation; positive regulation of transcription by RNA polymerase II; regulation of muscle cell differentiation; regulation of transcription by RNA polymerase II; skeletal muscle tissue development; transcription, DNA-templated; viral process
Reference #:  Q7TQK0-2 (UniProtKB)
Alt. Names/Synonyms: 2900041I18Rik; C81304; Ccnt2; CCNT2 iso3; cyclin T2; cyclin T2a; cyclin T2b; Cyclin-T2; CycT2; CycT2a; CycT2b
Gene Symbols: Ccnt2
Molecular weight: 72,940 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
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CCNT2 iso3

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein