|
DDX16
Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily. Note: This description may include information from UniProtKB.
|
| Protein type: EC 3.6.4.13; Helicase; RNA processing; RNA-binding; Spliceosome |
| Chromosomal Location of Human Ortholog: 6p21.33 |
|
Cellular Component:
nucleoplasm; nucleus; spliceosomal complex; U2-type precatalytic spliceosome
|
|
Molecular Function:
ATP binding; ATPase activity; protein binding; RNA helicase activity
|
|
Biological Process:
mRNA splicing, via spliceosome; RNA splicing
|
|
Disease: Neuromuscular Disease And Ocular Or Auditory Anomalies With Or Without Seizures
|
|
Reference #:
O60231
(UniProtKB)
|
|
Alt. Names/Synonyms: ATP-dependent RNA helicase #3; DBP2; DDX16; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16; DEAD/H box 16; DEAH (Asp-Glu-Ala-His) box polypeptide 16; DEAH-box helicase 16; DEAH-box protein 16; DHX16; KIAA0577; NMOAS; Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; PRO2014; Prp2; PRP8; PRPF2; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; RNA helicase
|
|
Gene Symbols: DHX16
|
|
Molecular weight:
119,264 Da
|
|
Basal Isoelectric point:
6.39
Predict pI for various phosphorylation states
|
