DDX16 Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase; RNA processing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 6p21.33
Cellular Component:  nucleoplasm; nucleus; spliceosomal complex; U2-type precatalytic spliceosome
Molecular Function:  ATP binding; ATPase activity; protein binding; RNA helicase activity
Biological Process:  mRNA splicing, via spliceosome; RNA splicing
Disease: Neuromuscular Disease And Ocular Or Auditory Anomalies With Or Without Seizures
Reference #:  O60231 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase #3; DBP2; DDX16; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16; DEAD/H box 16; DEAH (Asp-Glu-Ala-His) box polypeptide 16; DEAH-box helicase 16; DEAH-box protein 16; DHX16; KIAA0577; NMOAS; Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; PRO2014; Prp2; PRP8; PRPF2; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; RNA helicase
Gene Symbols: DHX16
Molecular weight: 119,264 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein