RANGAP1 GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export. Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export. Belongs to the RNA1 family. Highly expressed in brain, thymus and testis. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component:  aggresome; axon cytoplasm; condensed chromosome kinetochore; cytoplasm; cytoplasmic periphery of the nuclear pore complex; cytosol; dendrite; intracellular membrane-bounded organelle; mitotic spindle; nuclear envelope; nuclear membrane; nuclear pore; nuclear pore cytoplasmic filaments; nucleoplasm; perinuclear region of cytoplasm
Molecular Function:  GTPase activator activity; protein binding; Ran GTPase binding; RNA binding; ubiquitin protein ligase binding
Biological Process:  activation of GTPase activity; cellular response to vasopressin; negative regulation of protein export from nucleus; protein sumoylation; response to axon injury; signal transduction
Reference #:  P46060 (UniProtKB)
Alt. Names/Synonyms: Fug1; KIAA1835; MGC20266; RAGP1; Ran GTPase activating protein 1; Ran GTPase-activating protein 1; RANGAP; RANGAP1; SD; segregation distorter homolog; segregation distortion
Gene Symbols: RANGAP1
Molecular weight: 63,542 Da
Basal Isoelectric point: 4.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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