STXBP1 iso2
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Belongs to the STXBP/unc-18/SEC1 family. Brain and spinal cord. Highly enriched in axons. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
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Protein type: Vesicle |
Chromosomal Location of rat Ortholog: 3p11 |
Cellular Component:
axon; cytoplasm; cytosol; extrinsic component of presynaptic membrane; glutamatergic synapse; nucleoplasm; parallel fiber to Purkinje cell synapse; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane; platelet alpha granule; postsynapse; presynapse; presynaptic active zone cytoplasmic component; presynaptic active zone membrane; presynaptic cytosol; protein-containing complex; secretory granule
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Molecular Function:
identical protein binding; molecular adaptor activity; phospholipase binding; protein binding; protein domain specific binding; protein kinase binding; SNARE binding; syntaxin binding; syntaxin-1 binding
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Biological Process:
axon target recognition; cellular response to type II interferon; developmental process involved in reproduction; establishment of localization in cell; exocytosis; intracellular protein transport; long-term synaptic depression; negative regulation of neuron apoptotic process; negative regulation of protein-containing complex assembly; negative regulation of SNARE complex assembly; negative regulation of synaptic transmission, GABAergic; neuromuscular synaptic transmission; neuron apoptotic process; neurotransmitter secretion; platelet aggregation; platelet degranulation; positive regulation of calcium ion-dependent exocytosis; positive regulation of exocytosis; positive regulation of glutamate secretion, neurotransmission; positive regulation of mast cell degranulation; positive regulation of vesicle docking; presynaptic dense core vesicle exocytosis; protein localization to plasma membrane; protein stabilization; protein transport; regulation of acrosomal vesicle exocytosis; regulation of synaptic vesicle priming; regulation of vesicle fusion; response to estradiol; SNARE complex assembly; synaptic vesicle maturation; synaptic vesicle priming; vesicle docking involved in exocytosis; vesicle-mediated transport
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Reference #:
P61765-2
(UniProtKB)
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Alt. Names/Synonyms: Stxbp1; STXBP1 iso2; syntaxin binding protein 1; Syntaxin-binding protein 1
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Gene Symbols: Stxbp1
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Molecular weight:
68,736 Da
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Basal Isoelectric point:
6.32
Predict pI for various phosphorylation states
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