CBLIF Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis. Belongs to the eukaryotic cobalamin transport proteins family. Gastric mucosa. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of rat Ortholog: 1q43
Cellular Component:  apical plasma membrane; endosome; extracellular region; extracellular space; microvillus
Molecular Function:  cobalamin binding; vitamin binding
Biological Process:  cobalamin metabolic process; cobalamin transport; cobalt ion transport
Reference #:  P17267 (UniProtKB)
Alt. Names/Synonyms: Cblif; cobalamin binding intrinsic factor; Gastric intrinsic factor; GIF; INF; intrinsic factor
Gene Symbols: Cblif
Molecular weight: 45,956 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene