TSG101 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan. It may also play a role in the extracellular release of microvesicles that differ from the exosomes. Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nuclear receptor co-regulator
Chromosomal Location of rat Ortholog: 1q22
Cellular Component:  cytoplasm; cytosol; early endosome; early endosome membrane; endosome; endosome membrane; ESCRT I complex; extracellular exosome; Flemming body; late endosome; late endosome membrane; microtubule organizing center; nucleolus; nucleus; plasma membrane
Molecular Function:  calcium-dependent protein binding; nuclear receptor transcription coactivator activity; protein homodimerization activity; protein-containing complex binding; transcription corepressor activity; ubiquitin binding; ubiquitin protein ligase binding; virion binding
Biological Process:  cell cycle arrest; cell differentiation; cell division; endosome to lysosome transport; exosomal secretion; extracellular transport; keratinocyte differentiation; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor-activated receptor activity; negative regulation of transcription, DNA-templated; positive regulation of exosomal secretion; positive regulation of nucleic acid-templated transcription; positive regulation of ubiquitin-dependent endocytosis; positive regulation of viral budding via host ESCRT complex; positive regulation of viral release from host cell; protein monoubiquitination; protein transport; regulation of cell growth; regulation of extracellular exosome assembly; regulation of MAP kinase activity; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; viral budding
Reference #:  Q6IRE4 (UniProtKB)
Alt. Names/Synonyms: TSG101; Tumor susceptibility gene 101 protein
Gene Symbols: Tsg101
Molecular weight: 44,078 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  NURSA