ROD1 RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). Expressed in several hematopoietic cell lines examined. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 5q24
Cellular Component:  nucleus
Molecular Function:  RNA binding
Biological Process:  erythrocyte maturation; mRNA processing; negative regulation of mRNA splicing, via spliceosome; negative regulation of RNA splicing; regulation of cell differentiation; RNA splicing
Reference #:  Q9Z118 (UniProtKB)
Alt. Names/Synonyms: Polypyrimidine tract-binding protein 3; ROD1
Gene Symbols: Rod1
Molecular weight: 56,716 Da
Basal Isoelectric point: 9.2  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene