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LANP-L
Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. Belongs to the ANP32 family. Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Vesicle |
| Chromosomal Location of rat Ortholog: 2q34 |
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Cellular Component:
cytoplasm; cytoplasmic vesicle; nucleus; Swr1 complex
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Molecular Function:
histone binding; histone chaperone activity; phosphatase inhibitor activity; protein folding chaperone
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Biological Process:
chromatin organization; protein folding; regulation of apoptotic process
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Reference #:
Q5XIE0
(UniProtKB)
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Alt. Names/Synonyms: Acidic leucine-rich nuclear phosphoprotein 32 family member E; LANP-L
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Gene Symbols: Anp32e
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Molecular weight:
29,418 Da
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Basal Isoelectric point:
3.8
Predict pI for various phosphorylation states
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