EML1 Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. Belongs to the WD repeat EMAP family. Ubiquitous; expressed in most tissues with the exception of thymus and peripheral blood lymphocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Microtubule-binding
Chromosomal Location of Human Ortholog: 6q32
Cellular Component:  cytosol; microtubule; mitotic spindle midzone; mitotic spindle pole; perinuclear region of cytoplasm
Molecular Function:  microtubule binding; tubulin binding
Biological Process:  brain development; hematopoietic progenitor cell differentiation; microtubule cytoskeleton organization; mitotic spindle organization; neuroblast proliferation
Reference #:  Q4V8C3 (UniProtKB)
Alt. Names/Synonyms: Echinoderm microtubule-associated protein-like 1; EML1
Gene Symbols: Eml1
Molecular weight: 89,802 Da
Basal Isoelectric point: 6.56  Predict pI for various phosphorylation states
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EML1

Protein Structure Not Found.


Cross-references to other databases:  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene