FCER1G Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation. Belongs to the CD3Z/FCER1G family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 13q24
Cellular Component:  cell surface; external side of plasma membrane; Fc-epsilon receptor I complex; integral component of plasma membrane; plasma membrane
Molecular Function:  IgE binding; IgE receptor activity; IgG binding; protein binding; protein homodimerization activity
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell surface receptor signaling pathway; cellular response to low-density lipoprotein particle stimulus; defense response to bacterium; Fc receptor mediated stimulatory signaling pathway; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway; immunoglobulin mediated immune response; innate immune response; integrin-mediated signaling pathway; interleukin-2 production; interleukin-3-mediated signaling pathway; mast cell activation; negative regulation of mast cell apoptotic process; neutrophil activation involved in immune response; neutrophil chemotaxis; osteoclast differentiation; phagocytosis, engulfment; positive regulation of immune response; positive regulation of interleukin-10 production; positive regulation of interleukin-4 production; positive regulation of interleukin-6 production; positive regulation of mast cell cytokine production; positive regulation of mast cell degranulation; positive regulation of phagocytosis; positive regulation of protein localization to cell surface; positive regulation of tumor necrosis factor production; positive regulation of type I hypersensitivity; positive regulation of type IIa hypersensitivity; positive regulation of type III hypersensitivity; protein homooligomerization; protein localization to plasma membrane; receptor internalization; regulation of immune response; regulation of platelet activation; serotonin secretion by platelet; signal transduction; T cell differentiation involved in immune response
Reference #:  P20411 (UniProtKB)
Alt. Names/Synonyms: High affinity immunoglobulin epsilon receptor subunit gamma
Gene Symbols: Fcer1g
Molecular weight: 9,765 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene