GABRR2 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of rat Ortholog: 5q21
Cellular Component:  cell junction; chloride channel complex; GABA-A receptor complex; GABA-ergic synapse; integral component of membrane; integral component of plasma membrane; neuron projection; plasma membrane; postsynaptic membrane; synapse
Molecular Function:  chloride channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity; inhibitory extracellular ligand-gated ion channel activity; protein domain specific binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  chemical synaptic transmission; chloride transmembrane transport; gamma-aminobutyric acid signaling pathway; ion transmembrane transport; nervous system process; regulation of membrane potential; regulation of postsynaptic membrane potential; signal transduction; visual perception
Reference #:  P47742 (UniProtKB)
Alt. Names/Synonyms: GABRR2; Gamma-aminobutyric acid receptor subunit rho-2
Gene Symbols: Gabrr2
Molecular weight: 54,296 Da
Basal Isoelectric point: 9.12  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene