syntenin Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell adhesion; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 5q12
Cellular Component:  cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum membrane; extracellular exosome; focal adhesion; interleukin-5 receptor complex; intracellular membrane-bounded organelle; melanosome; membrane raft; nuclear membrane; nucleoplasm; plasma membrane
Molecular Function:  cell adhesion molecule binding; ephrin receptor binding; frizzled binding; growth factor binding; identical protein binding; interleukin-5 receptor binding; lipid binding; neurexin family protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; protein N-terminus binding; syndecan binding
Biological Process:  actin cytoskeleton organization; chemical synaptic transmission; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of receptor internalization; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of exosomal secretion; positive regulation of extracellular exosome assembly; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; presynapse assembly; Ras protein signal transduction; regulation of mitotic cell cycle
Reference #:  Q9JI92 (UniProtKB)
Alt. Names/Synonyms: syntenin; Syntenin-1
Gene Symbols: Sdcbp
Molecular weight: 32,423 Da
Basal Isoelectric point: 7.05  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  UniProtKB  |  Entrez-Gene