PF4 Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. Belongs to the intercrine alpha (chemokine CxC) family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of rat Ortholog: 14p22
Cellular Component:  cytoplasm; extracellular space; other organism cytoplasm; platelet alpha granule; protein-containing complex; symbiont-containing vacuole membrane; vesicle
Molecular Function:  chemokine activity; CXCR3 chemokine receptor binding; heparin binding
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; antimicrobial humoral immune response mediated by antimicrobial peptide; cellular response to lipopolysaccharide; chemokine-mediated signaling pathway; cytokine-mediated signaling pathway; defense response to protozoan; immune response; inflammatory response; killing by host of symbiont cells; leukocyte chemotaxis; negative regulation of angiogenesis; negative regulation of cytolysis; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of megakaryocyte differentiation; negative regulation of MHC class II biosynthetic process; neutrophil chemotaxis; platelet activation; positive regulation of gene expression; positive regulation of macrophage derived foam cell differentiation; positive regulation of macrophage differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; protein-containing complex assembly; regulation of cell proliferation; regulation of signaling receptor activity
Reference #:  P06765 (UniProtKB)
Alt. Names/Synonyms: C-X-C motif chemokine 4; Cxcl4; PF-4; PF4; Platelet factor 4; Scyb4
Gene Symbols: Pf4
Molecular weight: 11,287 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein