PAICS
In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 4.1.1.21; EC 6.3.2.6; Ligase; Lyase; Nucleotide Metabolism - purine |
Chromosomal Location of rat Ortholog: 14p11 |
Cellular Component:
cytoplasm
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Molecular Function:
5-amino-4-imidazole carboxylate lyase activity; ATP binding; carboxy-lyase activity; identical protein binding; phosphoribosylaminoimidazole carboxylase activity; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
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Biological Process:
'de novo' AMP biosynthetic process; 'de novo' IMP biosynthetic process; 'de novo' XMP biosynthetic process; G1/S transition of mitotic cell cycle; GMP biosynthetic process; purine nucleobase biosynthetic process
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Reference #:
P51583
(UniProtKB)
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Alt. Names/Synonyms: Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; Multifunctional protein ADE2; PAICS
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Gene Symbols: Paics
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Molecular weight:
47,096 Da
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Basal Isoelectric point:
7.87
Predict pI for various phosphorylation states
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