ZNF238
Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily. Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: C2H2-type zinc finger protein; Transcription factor |
Chromosomal Location of rat Ortholog: 13q25 |
Cellular Component:
heterochromatin; nuclear speck; nucleoplasm; nucleus
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Molecular Function:
DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
cerebellum development; cerebral cortex development; hippocampus development; homeostasis of number of cells; in utero embryonic development; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; neuron development; positive regulation of transcription by RNA polymerase II; regulation of cell division; regulation of transcription by RNA polymerase II; skeletal muscle tissue development
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Reference #:
Q9JKY3
(UniProtKB)
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Alt. Names/Synonyms: Zinc finger and BTB domain-containing protein 18; ZNF238
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Gene Symbols: Zbtb18
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Molecular weight:
58,310 Da
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Basal Isoelectric point:
5.41
Predict pI for various phosphorylation states
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