PDE1C Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. Isoform PDE1C2 is present in the heart and brain and, at lower levels in the lung, liver, kidney and skeletal muscle (PubMed:8557689). Isoform PDE1C1 is expressed in the heart and brain and, at lower levels in lung (PubMed:8557689). Also expressed at low levels in uterus and testis (PubMed:8557689). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of rat Ortholog: 4q24
Cellular Component:  cilium; neuronal cell body
Molecular Function:  3',5'-cyclic-nucleotide phosphodiesterase activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; calmodulin binding; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; cAMP binding; metal ion binding
Biological Process:  negative regulation of insulin secretion involved in cellular response to glucose stimulus; response to calcium ion; sensory perception of smell; signal transduction
Reference #:  Q63421 (UniProtKB)
Alt. Names/Synonyms: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; PDE1C
Gene Symbols: Pde1c
Molecular weight: 86,671 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene