RAB11A The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes. Belongs to the small GTPase superfamily. Rab family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis
Chromosomal Location of rat Ortholog: 8q24
Cellular Component:  axon; centrosome; cleavage furrow; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; endosome; exocytic vesicle; extracellular exosome; glutamatergic synapse; intracellular membrane-bounded organelle; kinetochore microtubule; membrane; microtubule organizing center; multivesicular body; perinuclear region of cytoplasm; phagocytic vesicle; postsynaptic recycling endosome; protein-containing complex; recycling endosome; recycling endosome membrane; Schaffer collateral - CA1 synapse; spindle pole; trans-Golgi network; transport vesicle; vesicle
Molecular Function:  GTP binding; GTPase activity; microtubule binding; myosin V binding; protein domain specific binding
Biological Process:  amyloid-beta clearance by transcytosis; astral microtubule organization; establishment of protein localization to membrane; establishment of protein localization to organelle; establishment of vesicle localization; exocytosis; exosomal secretion; intracellular cholesterol transport; intracellular protein transport; melanosome transport; mitotic metaphase plate congression; mitotic spindle assembly; multivesicular body assembly; neuron projection development; neurotransmitter receptor transport, endosome to postsynaptic membrane; positive regulation of axon extension; positive regulation of epithelial cell migration; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of protein localization to plasma membrane; protein localization to plasma membrane; Rab protein signal transduction; regulation of cytokinesis; regulation of long-term neuronal synaptic plasticity; regulation of multivesicular body size; regulation of protein transport; regulation of vesicle-mediated transport; vesicle-mediated transport; vesicle-mediated transport in synapse
Reference #:  P62494 (UniProtKB)
Alt. Names/Synonyms: RAB11A; Ras-related protein Rab-11A
Gene Symbols: Rab11a
Molecular weight: 24,394 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene