RAD18 E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. Belongs to the RAD18 family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 3p25.3
Cellular Component:  centrosome; cytoplasm; nuclear body; nuclear inclusion body; nucleoplasm; nucleus; replication fork; site of double-strand break
Molecular Function:  damaged DNA binding; identical protein binding; metal ion binding; polyubiquitin modification-dependent protein binding; protein binding; protein-containing complex binding; single-stranded DNA binding; ubiquitin protein ligase binding; Y-form DNA binding
Biological Process:  cellular response to DNA damage stimulus; DNA damage response, detection of DNA damage; DNA repair; negative regulation of cell death; positive regulation of chromosome segregation; protein autoubiquitination; protein ubiquitination
Reference #:  Q9NS91 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; postreplication repair protein hRAD18p; Postreplication repair protein RAD18; RAD18; RAD18 E3 ubiquitin protein ligase; RAD18 homolog; RAD18 homolog (S. cerevisiae); RAD18, S. cerevisiae, homolog; RING finger protein 73; RING-type E3 ubiquitin transferase RAD18; RNF73
Gene Symbols: RAD18
Molecular weight: 56,223 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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