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IRF5 iso2
Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Belongs to the IRF family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 7q32.1 |
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Cellular Component:
chromatin; cytoplasm; cytosol; nucleus
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Molecular Function:
DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
cellular response to virus; cytokine-mediated signaling pathway; defense response to virus; immune system process; inflammatory response; innate immune response; positive regulation of apoptotic process; positive regulation of cytokine production involved in immune response; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of interleukin-12 production; positive regulation of transcription by RNA polymerase II; positive regulation of type I interferon production; regulation of transcription by RNA polymerase II; response to muramyl dipeptide; response to peptidoglycan
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Reference #:
Q13568-2
(UniProtKB)
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Alt. Names/Synonyms: Interferon regulatory factor 5; interferon regulatory factor 5 isoform d; IRF-5; IRF5; IRF5 iso2; OTTHUMP00000212904; OTTHUMP00000212905; OTTHUMP00000212907; OTTHUMP00000212910; Q13568-2; Q13568-3; SLEB10
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Gene Symbols: IRF5
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Molecular weight:
57,770 Da
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Basal Isoelectric point:
5.61
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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