MORF4L1 iso2 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 15q25.1
Cellular Component:  NuA4 histone acetyltransferase complex; nuclear speck; nucleoplasm; Sin3 complex
Molecular Function:  protein binding; protein N-terminus binding
Biological Process:  double-strand break repair via homologous recombination; histone deacetylation; histone H2A acetylation; histone H4 acetylation; regulation of growth
Reference #:  Q9UBU8-2 (UniProtKB)
Alt. Names/Synonyms: Eaf3; Esa1p-associated factor 3; Esa1p-associated factor 3 homolog; FWP006; HSPC008; HsT17725; MEAF3; MGC10631; MO4L1; MORF-related gene 15 protein; MORF-related gene on chromosome 15; MORF4L1; MORF4L1 iso2; MORFRG15; mortality factor 4 like 1; Mortality factor 4-like protein 1; mortality factor 4-like protein 1 isoform 1; MRG15; OTTHUMP00000185040; protein MSL3-1; Q9UBU8-2; S863-6; transcription factor-like protein MRG15
Gene Symbols: MORF4L1
Molecular weight: 37,231 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
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MORF4L1 iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein