tensin 2 iso4 Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cell cycle regulation; EC 3.1.3.-; Phosphatase
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  focal adhesion; plasma membrane
Molecular Function:  kinase binding; metal ion binding; phosphoprotein phosphatase activity; protein binding
Biological Process:  cellular homeostasis; collagen metabolic process; intracellular signal transduction; kidney development; multicellular organism growth; multicellular organismal homeostasis; negative regulation of cell proliferation; protein dephosphorylation; response to muscle activity
Reference #:  Q63HR2-4 (UniProtKB)
Alt. Names/Synonyms: C1 domain-containing phosphatase and tensin; C1 domain-containing phosphatase and tensin-like protein splice variant 2; C1-TEN; C1TEN; DKFZp686D13244; FLJ16320; KIAA1075; Q63HR2-4; TENC1; tensin 2; tensin like C1 domain containing phosphatase (tensin 2); tensin like C1 domain-containing phosphatase; Tensin-2; tensin-like C1 domain-containing phosphatase; tensin-like C1 domain-containing phosphatase isoform 1; TNS2
Gene Symbols: TNS2
Molecular weight: 153,564 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
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tensin 2 iso4

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein