CSDA Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression. Highly expressed in skeletal muscle and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12p13.2
Cellular Component:  bicellular tight junction; cytoplasm; cytosol; nucleus; perinuclear region of cytoplasm
Molecular Function:  DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; mRNA 3'-UTR binding; polysome binding; protein binding; Rho GTPase binding; RNA polymerase II regulatory region sequence-specific DNA binding; transcription corepressor activity
Biological Process:  3'-UTR-mediated mRNA stabilization; cellular hyperosmotic response; cellular response to tumor necrosis factor; fertilization; in utero embryonic development; male gonad development; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; negative regulation of necroptotic process; negative regulation of skeletal muscle tissue development; negative regulation of transcription by RNA polymerase II; positive regulation of cytoplasmic translation; positive regulation of organ growth; response to cold; spermatogenesis
Reference #:  P16989 (UniProtKB)
Alt. Names/Synonyms: cold shock domain protein A; Cold shock domain-containing protein A; cold-shock domain containing A1; cold-shock domain protein A; CSDA; CSDA1; DBPA; DNA-binding protein A; NF-GMB; Single-strand DNA-binding protein NF-GMB; Y-box-binding protein 3; ZO-1-associated nucleic acid-binding protein; ZONAB
Gene Symbols: YBX3
Molecular weight: 40,090 Da
Basal Isoelectric point: 9.77  Predict pI for various phosphorylation states
Select Structure to View Below

CSDA

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein