NFAT90 a double-stranded RNA (dsRNA)-binding protein implicated in the regulation of gene expression . Phosphorylated in a double-stranded RNA-dependent manner possibly by PKR. Five different splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nucleolus; RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component:  cytoplasm; mitochondrion; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function:  DNA binding; double-stranded RNA binding; mRNA 3'-UTR AU-rich region binding; protein binding; RNA binding
Biological Process:  defense response to virus; negative regulation of transcription, DNA-templated; negative regulation of translation; negative regulation of viral genome replication; positive regulation of transcription, DNA-templated; protein phosphorylation
Reference #:  Q12906 (UniProtKB)
Alt. Names/Synonyms: CBTF; Double-stranded RNA-binding protein 76; double-stranded RNA-binding protein, 76 kD; DRBF; DRBP76; dsRNA binding protein NFAR-2/MPP4; ILF3; interleukin enhancer binding factor 3, 90kDa; Interleukin enhancer-binding factor 3; M-phase phosphoprotein 4; MMP4; MPHOSPH4; MPP4; NF-AT-90; NF110; NF90; NFAR; NFAR-1; NFAR2; Nuclear factor associated with dsRNA; Nuclear factor of activated T-cells 90 kDa; nuclear factor of activated T-cells, 90 kD; TCP110; TCP80; Translational control protein 80
Gene Symbols: ILF3
Molecular weight: 95,338 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
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NFAT90

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein