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SYNE2
Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Belongs to the nesprin family. Widely expressed, with higher level in kidney, adult and fetal liver, stomach and placenta. Weakly expressed in skeletal muscle and brain. Isoform 5 is highly expressed in pancreas, skeletal muscle and heart. 13 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 14q23.2 |
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Cellular Component:
cytoplasm; filopodium membrane; focal adhesion; intermediate filament cytoskeleton; lamellipodium membrane; meiotic nuclear membrane microtubule tethering complex; mitochondrion; nuclear envelope; nuclear lumen; nuclear membrane; nuclear outer membrane; nucleoplasm; nucleus; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; Z disc
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Molecular Function:
actin binding; cytoskeleton-nuclear membrane anchor activity; protein binding
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Biological Process:
centrosome localization; nuclear migration; nuclear migration along microfilament; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration; positive regulation of cell migration; regulation of cilium assembly
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Disease: Emery-dreifuss Muscular Dystrophy 5, Autosomal Dominant
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Reference #:
Q8WXH0
(UniProtKB)
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Alt. Names/Synonyms: DKFZp434H2235; DKFZp686E01115; DKFZp686H1931; EDMD5; FLJ11014; FLJ43727; FLJ45710; FLJ46790; KASH domain-containing protein 2; KASH2; KIAA1011; Nesp2; nesprin 2; Nesprin-2; NUA; NUANCE; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element protein; polytrophin; Protein NUANCE; spectrin repeat containing nuclear envelope protein 2; spectrin repeat containing, nuclear envelope 2; Synaptic nuclear envelope protein 2; synaptic nuclei expressed gene 2; Syne-2; SYNE2; TROPH
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Gene Symbols: SYNE2
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Molecular weight:
796,442 Da
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Basal Isoelectric point:
5.26
Predict pI for various phosphorylation states
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