MRE11A Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. Belongs to the MRE11/RAD32 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease
Chromosomal Location of human Ortholog: 11q21
Cellular Component:  cytoplasm; cytosol; Mre11 complex; nuclear chromosome, telomeric region; nucleoplasm; nucleus; PML body; replication fork; site of double-strand break
Molecular Function:  3'-5' exonuclease activity; 5'-3' exonuclease activity; double-stranded DNA binding; endodeoxyribonuclease activity; identical protein binding; manganese ion binding; nuclease activity; protein binding; protein C-terminus binding; single-stranded DNA endodeoxyribonuclease activity
Biological Process:  cell proliferation; cellular response to DNA damage stimulus; DNA double-strand break processing; DNA duplex unwinding; DNA recombination; DNA repair; DNA replication; DNA strand resection involved in replication fork processing; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; negative regulation of apoptotic process; negative regulation of DNA endoreduplication; positive regulation of kinase activity; positive regulation of protein autophosphorylation; positive regulation of telomere maintenance; positive regulation of type I interferon production; reciprocal meiotic recombination; regulation of mitotic recombination; regulation of signal transduction by p53 class mediator; sister chromatid cohesion; synapsis; telomere maintenance via telomerase; telomeric 3' overhang formation; viral process
Disease: Ataxia-telangiectasia-like Disorder 1
Reference #:  P49959 (UniProtKB)
Alt. Names/Synonyms: AT-like disease; ATLD; DNA recombination and repair protein; Double-strand break repair protein MRE11; Double-strand break repair protein MRE11A; endo/exonuclease Mre11; HNGS1; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A; MRE11; MRE11 double strand break repair nuclease A; MRE11 homolog 1; MRE11 homolog A; MRE11 homolog A, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae); MRE11 meiotic recombination 11-like protein A; MRE11A; MRE11B
Gene Symbols: MRE11
Molecular weight: 80,593 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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