|
MIER1
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 1p31.3 |
|
Cellular Component:
cytoplasm; nucleoplasm; nucleus; protein-containing complex; transcription repressor complex
|
|
Molecular Function:
histone deacetylase activity; histone deacetylase binding; protein binding; transcription corepressor activity
|
|
Biological Process:
chromatin remodeling; histone deacetylation; negative regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription
|
|
Reference #:
Q8N108
(UniProtKB)
|
|
Alt. Names/Synonyms: DKFZp781G0451; Early response 1; Er1; hMi-er1; KIAA1610; mesoderm induction early response 1 (MI-ER1); mesoderm induction early response 1 homolog; mesoderm induction early response 1 homolog (Xenopus laevis); mesoderm induction early response 1, transcriptional regulator; Mesoderm induction early response protein 1; MGC131940; MGC150640; MGC150641; Mi-er1; MIER1; MIER1 transcriptional regulator; RP5-944N15.1
|
|
Gene Symbols: MIER1
|
|
Molecular weight:
57,983 Da
|
|
Basal Isoelectric point:
4.34
Predict pI for various phosphorylation states
|
