MIER1 Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component:  cytoplasm; nucleoplasm; nucleus; protein-containing complex; transcriptional repressor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding; protein binding
Biological Process:  histone deacetylation; positive regulation of chromatin silencing
Reference #:  Q8N108 (UniProtKB)
Alt. Names/Synonyms: DKFZp781G0451; Early response 1; Er1; hMi-er1; KIAA1610; mesoderm induction early response 1 (MI-ER1); mesoderm induction early response 1 homolog; mesoderm induction early response 1 homolog (Xenopus laevis); mesoderm induction early response 1, transcriptional regulator; Mesoderm induction early response protein 1; MGC131940; MGC150640; MGC150641; Mi-er1; MIER1; MIER1 transcriptional regulator; RP5-944N15.1
Gene Symbols: MIER1
Molecular weight: 57,983 Da
Basal Isoelectric point: 4.34  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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