MCM3 Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation. Belongs to the MCM family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC
Chromosomal Location of Human Ortholog: 6p12.2
Cellular Component:  alpha DNA polymerase:primase complex; centrosome; MCM complex; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function:  ATP binding; DNA binding; helicase activity; protein binding
Biological Process:  DNA replication; DNA replication initiation; G1/S transition of mitotic cell cycle
Reference #:  P25205 (UniProtKB)
Alt. Names/Synonyms: cervical cancer proto-oncogene 5; DNA polymerase alpha holoenzyme-associated protein P1; DNA replication factor MCM3; DNA replication licensing factor MCM3; HCC5; hRlf beta subunit; MCM3; MCM3 minichromosome maintenance deficient 3; MGC1157; minichromosome maintenance complex component 3; minichromosome maintenance deficient 3; P1-MCM3; P1.h; p102; replication licensing factor, beta subunit; RLF subunit beta; RLFB
Gene Symbols: MCM3
Molecular weight: 90,981 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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