EAP1 Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance. Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter. Belongs to the IRF2BP family. Highly expressed in the heart, moderately in skeletal muscle and pancreas, and weakly in brain, kidney, liver, testis, thyroid gland and lymphocytes. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  metal ion binding; protein binding; ubiquitin protein ligase activity
Biological Process:  development of secondary female sexual characteristics; negative regulation of transcription by RNA polymerase II; nervous system development; positive regulation of transcription by RNA polymerase II; protein ubiquitination
Disease: Neurodevelopmental Disorder With Regression, Abnormal Movements, Loss Of Speech, And Seizures
Reference #:  Q9H1B7 (UniProtKB)
Alt. Names/Synonyms: C14orf4; chromosome 14 open reading frame 4; EAP1; enhanced at puberty 1; Enhanced at puberty protein 1; I2BPL; interferon regulatory factor 2 binding protein like; Interferon regulatory factor 2-binding protein-like; IRF2BPL; KIAA1865; NEDAMSS; Probable E3 ubiquitin-protein ligase IRF2BPL
Gene Symbols: IRF2BPL
Molecular weight: 82,659 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB