|
NPL4
The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I. Belongs to the NPL4 family. Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Endoplasmic reticulum; Ubiquitin conjugating system |
| Chromosomal Location of human Ortholog: 17q25.3 |
|
Cellular Component:
cytosol; endoplasmic reticulum; nuclear outer membrane-endoplasmic reticulum membrane network; nucleoplasm; nucleus; UFD1-NPL4 complex; VCP-NPL4-UFD1 AAA ATPase complex
|
|
Molecular Function:
ATPase binding; K48-linked polyubiquitin modification-dependent protein binding; K63-linked polyubiquitin modification-dependent protein binding; metal ion binding; protein binding; protein-containing complex binding; ubiquitin binding; ubiquitin protein ligase binding
|
|
Biological Process:
Golgi organization; negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway; ubiquitin-dependent protein catabolic process
|
|
Reference #:
Q8TAT6
(UniProtKB)
|
|
Alt. Names/Synonyms: FLJ20657; FLJ23742; KIAA1499; NPL4; NPL4 homolog, ubiquitin recognition factor; NPLOC4; NPLOC4 ubiquitin recognition factor; nuclear protein localization 4 homolog; nuclear protein localization 4 homolog (S. cerevisiae); Nuclear protein localization protein 4 homolog; Protein NPL4
|
|
Gene Symbols: NPLOC4
|
|
Molecular weight:
68,120 Da
|
|
Basal Isoelectric point:
5.94
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
