ESYT2 Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Belongs to the extended synaptotagmin family. Widely expressed with high level in cerebellum. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 7q36.3
Cellular Component:  endoplasmic reticulum membrane; extrinsic component of cytoplasmic side of plasma membrane; integral component of plasma membrane; intrinsic component of endoplasmic reticulum membrane; organelle membrane contact site
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding; identical protein binding; phosphatidylcholine binding; phosphatidylethanolamine binding; phosphatidylinositol binding; protein binding
Biological Process:  endocytosis; endoplasmic reticulum-plasma membrane tethering; glycosphingolipid metabolic process; lipid transport
Reference #:  A0FGR8 (UniProtKB)
Alt. Names/Synonyms: chr2 synaptotagmin; Chr2Syt; E-Syt2; ESYT2; extended synaptotagmin 2; extended synaptotagmin like protein 2; extended synaptotagmin protein 2; Extended synaptotagmin-2; extended synaptotagmin-like protein 2; FAM62B; family with sequence similarity 62 (C2 domain containing) member B; family with sequence similarity 62 (C2 domain containing), member B; KIAA1228
Gene Symbols: ESYT2
Molecular weight: 102,357 Da
Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene