SH2BP1 Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation
Chromosomal Location of human Ortholog: 11p15.4
Cellular Component:  Cdc73/Paf1 complex; euchromatin; nuclear speck; nucleoplasm
Molecular Function:  protein binding; RNA polymerase II complex binding; SH2 domain binding
Biological Process:  blastocyst growth; blastocyst hatching; cellular response to lipopolysaccharide; endodermal cell fate commitment; histone H2B ubiquitination; histone H3-K4 trimethylation; histone monoubiquitination; inner cell mass cell differentiation; interleukin-6-mediated signaling pathway; negative regulation of myeloid cell differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K79 methylation; receptor signaling pathway via JAK-STAT; regulation of DNA-templated transcription; regulation of genetic imprinting; regulation of histone H3-K4 methylation; stem cell population maintenance; transcription elongation by RNA polymerase II promoter; trophectodermal cell differentiation; Wnt signaling pathway
Reference #:  Q6PD62 (UniProtKB)
Alt. Names/Synonyms: CTR9; CTR9 homolog, Paf1/RNA polymerase II complex component; Ctr9, Paf1/RNA polymerase II complex component, homolog; Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); KIAA0155; p150; p150TSP; RNA polymerase-associated protein CTR9 homolog; SH2 domain binding protein 1 (tetratricopeptide repeat containing); SH2 domain-binding protein 1; SH2BP1; TPR-containing, SH2-binding phosphoprotein; TSBP
Gene Symbols: CTR9
Molecular weight: 133,502 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SH2BP1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene