|
DLG7
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. Belongs to the SAPAP family. Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cell cycle regulation; Microtubule-binding |
| Chromosomal Location of human Ortholog: 14q22.3 |
|
Cellular Component:
cytoplasm; cytosol; mitotic spindle; nucleus; spindle pole centrosome
|
|
Molecular Function:
microtubule binding; protein binding
|
|
Biological Process:
centrosome localization; chromosome segregation; kinetochore assembly; mitotic chromosome movement towards spindle pole; mitotic spindle organization; positive regulation of mitotic metaphase/anaphase transition; regulation of mitotic cell cycle; signaling
|
|
Reference #:
Q15398
(UniProtKB)
|
|
Alt. Names/Synonyms: DAP-5; Discs large homolog 7; discs large homolog associated protein 5; discs, large (Drosophila) homolog-associated protein 5; discs, large homolog 7; Disks large-associated protein 5; Disks large-associated protein DLG7; DLG associated protein 5; DLG7; DLGAP5; DLGP5; Drosophila discs large-1 tumor suppressor-like; Hepatoma up-regulated protein; HURP; KIAA0008
|
|
Gene Symbols: DLGAP5
|
|
Molecular weight:
95,115 Da
|
|
Basal Isoelectric point:
9.11
Predict pI for various phosphorylation states
|
