GTF3C4 Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box. Belongs to the TFIIIC subunit 4 family. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC
Chromosomal Location of Human Ortholog: 9q34.13
Cellular Component:  mitochondrion; nucleoplasm; nucleus; transcription factor TFIIIC complex
Molecular Function:  enzyme activator activity; histone acetyltransferase activity; protein binding
Biological Process:  5S class rRNA transcription by RNA polymerase III; histone acetylation; positive regulation of catalytic activity; transcription by RNA polymerase III; transcription initiation from RNA polymerase III promoter; tRNA transcription by RNA polymerase III
Reference #:  Q9UKN8 (UniProtKB)
Alt. Names/Synonyms: FLJ21002; general transcription factor 3C 4; General transcription factor 3C polypeptide 4; general transcription factor IIIC, polypeptide 4, 90kDa; GTF3C4; KAT12; MGC138450; TF3C-delta; TF3C4; TFIII90; TFIIIC 90 kDa subunit; TFIIIC290; TFIIIC90; TFIIICDELTA; Transcription factor IIIC 90 kDa subunit; Transcription factor IIIC subunit delta
Gene Symbols: GTF3C4
Molecular weight: 91,982 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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