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GTF3C4
Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box. Belongs to the TFIIIC subunit 4 family. Note: This description may include information from UniProtKB.
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| Protein type: Acetyltransferase; EC 2.3.1.48 |
| Chromosomal Location of human Ortholog: 9q34.13 |
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Cellular Component:
mitochondrion; nucleoplasm; transcription factor TFIIIC complex
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Molecular Function:
DNA binding; enzyme activator activity; histone acetyltransferase activity; protein binding; RNA polymerase III general transcription initiation factor activity
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Biological Process:
5S class rRNA transcription by RNA polymerase III; chromatin remodeling; transcription by RNA polymerase III; transcription initiation at RNA polymerase III promoter; tRNA transcription by RNA polymerase III
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Reference #:
Q9UKN8
(UniProtKB)
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Alt. Names/Synonyms: FLJ21002; general transcription factor 3C 4; General transcription factor 3C polypeptide 4; general transcription factor IIIC subunit 4; general transcription factor IIIC, polypeptide 4, 90kDa; GTF3C4; KAT12; MGC138450; TF3C-delta; TF3C4; TFIII90; TFIIIC 90 kDa subunit; TFIIIC290; TFIIIC90; TFIIICDELTA; Transcription factor IIIC 90 kDa subunit; Transcription factor IIIC subunit delta
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Gene Symbols: GTF3C4
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Molecular weight:
91,982 Da
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Basal Isoelectric point:
6.21
Predict pI for various phosphorylation states
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