PTPLAD1 Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization. Belongs to the very long-chain fatty acids dehydratase HACD family. Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 15q22.31
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; nuclear membrane
Molecular Function:  3-hydroxyacyl-CoA dehydratase activity; enzyme binding; GTPase activator activity; protein binding
Biological Process:  fatty acid elongation; I-kappaB kinase/NF-kappaB signaling; JNK cascade; positive regulation by virus of viral protein levels in host cell; positive regulation of viral genome replication; Rac protein signal transduction; Rho protein signal transduction; small GTPase mediated signal transduction; sphingolipid biosynthetic process; very long-chain fatty acid biosynthetic process
Reference #:  Q9P035 (UniProtKB)
Alt. Names/Synonyms: 3-hydroxyacyl-CoA dehydratase 3; B-ind1; BIND1; Butyrate-induced protein 1; butyrate-induced transcript 1; FLJ90376; HACD3; hB-ind1; HSPC121; protein tyrosine phosphatase-like A domain containing 1; Protein tyrosine phosphatase-like protein PTPLAD1; Protein-tyrosine phosphatase-like A domain-containing protein 1; PTAD1; PTPLAD1; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3; Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
Gene Symbols: HACD3
Molecular weight: 43,160 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein