WAPL Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Belongs to the WAPL family. Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of human Ortholog: 10q23.2
Cellular Component:  chromatin; chromosome; chromosome, centromeric region; cytoplasm; cytosol; intercellular bridge; intracellular membrane-bounded organelle; mitotic spindle; nucleoplasm; nucleus
Molecular Function:  ATP-dependent protein-DNA unloader activity; protein binding
Biological Process:  cell division; mitotic sister chromatid segregation; negative regulation of chromatin binding; negative regulation of DNA replication; negative regulation of sister chromatid cohesion; protein localization to chromatin; regulation of cohesin loading
Reference #:  Q7Z5K2 (UniProtKB)
Alt. Names/Synonyms: FOE; friend of EBNA2 (Epstein-Barr virus nuclear protein 2); Friend of EBNA2 protein; KIAA0261; WAPAL; WAPL; WAPL cohesin release factor; wings apart-like homolog (Drosophila); Wings apart-like protein homolog
Gene Symbols: WAPL
Molecular weight: 132,946 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein