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FLN29
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 12q24.13 |
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Cellular Component:
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Molecular Function:
metal ion binding; protein binding
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Biological Process:
negative regulation of innate immune response
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Reference #:
O14545
(UniProtKB)
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Alt. Names/Synonyms: FLN29; FLN29 gene product; Protein FLN29; TRAD1; TRAF-type zinc finger domain containing 1; TRAF-type zinc finger domain-containing protein 1; TRAFD1
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Gene Symbols: TRAFD1
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Molecular weight:
64,841 Da
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Basal Isoelectric point:
5.19
Predict pI for various phosphorylation states
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