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NKAP
Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. Belongs to the NKAP family. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: Xq24 |
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Cellular Component:
cytosol; nucleoplasm; nucleus
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Molecular Function:
chromatin binding; chromatin DNA binding; protein binding
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Biological Process:
granulocyte differentiation; hematopoietic stem cell proliferation; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; positive regulation of alpha-beta T cell differentiation; somatic stem cell population maintenance; T cell differentiation in thymus
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Disease: Intellectual Developmental Disorder, X-linked, Syndromic, Hackmann-di Donato Type
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Reference #:
Q8N5F7
(UniProtKB)
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Alt. Names/Synonyms: FLJ22626; MRXSHD; NF kappaB activating protein; NF-kappa-B-activating protein; NF-kappaB activating protein; NFKB activating protein; NKAP
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Gene Symbols: NKAP
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Molecular weight:
47,138 Da
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Basal Isoelectric point:
10.12
Predict pI for various phosphorylation states
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