NKAP Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. Belongs to the NKAP family. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: Xq24
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  chromatin binding; chromatin DNA binding; protein binding
Biological Process:  granulocyte differentiation; hematopoietic stem cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; Notch signaling pathway; positive regulation of alpha-beta T cell differentiation; stem cell population maintenance; T cell differentiation in thymus
Disease: Intellectual Developmental Disorder, X-linked, Syndromic, Hackmann-di Donato Type
Reference #:  Q8N5F7 (UniProtKB)
Alt. Names/Synonyms: FLJ22626; NF kappaB activating protein; NF-kappa-B-activating protein; NF-kappaB activating protein; NFKB activating protein; NKAP
Gene Symbols: NKAP
Molecular weight: 47,138 Da
Basal Isoelectric point: 10.12  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene