NSUN2 RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity. Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily. Expressed in adult and fetal brain and in lymphoblastoid cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Methyltransferase; Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 5p15.31
Cellular Component:  chromatoid body; cytoplasm; nucleolus; nucleoplasm; spindle
Molecular Function:  tRNA (cytosine-5-)-methyltransferase activity
Biological Process:  cell division; hair follicle maturation; meiotic cell cycle checkpoint; spermatid development; tRNA methylation; tRNA modification
Disease: Mental Retardation, Autosomal Recessive 5
Reference #:  Q08J23 (UniProtKB)
Alt. Names/Synonyms: 5-methycytoisine methyltransferase; cDNA FLJ76184, highly similar to Homo sapiens NOL1/NOP2/Sun domain family, member 2 (NSUN2), mRNA; FLJ20303; hTrm4; MISU; Myc-induced SUN-domain-containing protein; NOL1/NOP2/Sun domain family 2; NOL1/NOP2/Sun domain family member 2; NOL1/NOP2/Sun domain family, member 2; NOP2/Sun domain family, member 2; NSUN2; SAKI; substrate of AIM1/Aurora kinase B; TRM4; tRNA (cytosine(34)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase NSUN2; tRNA methyltransferase 4 homolog
Gene Symbols: NSUN2
Molecular weight: 86,471 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB