SMEK1 a conserved single-pass membrane protein. In Dictyostelium, the SMEK homolog regulates myosin II assembly and cytokinesis during vegetative growth. Loss of SMEK suppresses defects in cell polarity, chemotaxis, and gene expression in MEK1 null cells. Six alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 14q32.12
Cellular Component:  cytoplasm; microtubule organizing center; nucleoplasm
Reference #:  Q6IN85 (UniProtKB)
Alt. Names/Synonyms: FLFL1; KIAA2010; MSTP033; P4R3A; PP4R3A; PPP4R3A; Serine/threonine-protein phosphatase 4 regulatory subunit 3A; SMEK homolog 1; SMEK homolog 1, suppressor of mek1 (Dictyostelium); SMEK1; smk-1; smk1
Gene Symbols: PPP4R3A
Molecular weight: 95,368 Da
Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein