|
ANKZF1
Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Belongs to the ANKZF1/VMS1 family. Note: This description may include information from UniProtKB.
|
| Protein type: C2H2-type zinc finger protein |
| Chromosomal Location of human Ortholog: 2q35 |
|
Cellular Component:
cytoplasm
|
|
Molecular Function:
catalytic activity, acting on a tRNA; metal ion binding; protein binding; RNA endonuclease activity
|
|
Biological Process:
cellular response to hydrogen peroxide; protein quality control for misfolded or incompletely synthesized proteins; rescue of stalled ribosome; ubiquitin-dependent ERAD pathway
|
|
Reference #:
Q9H8Y5
(UniProtKB)
|
|
Alt. Names/Synonyms: ankyrin repeat and zinc finger domain containing 1; Ankyrin repeat and zinc finger domain-containing protein 1; ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1; ANKZ1; ANKZF1; FLJ10415; FLJ13144; tRNA endonuclease ANKZF1; VMS1; Zinc finger protein 744; ZNF744
|
|
Gene Symbols: ANKZF1
|
|
Molecular weight:
80,927 Da
|
|
Basal Isoelectric point:
8.69
Predict pI for various phosphorylation states
|
