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DYNC1I2
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. Belongs to the dynein intermediate chain family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor |
| Chromosomal Location of human Ortholog: 2q31.1 |
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Cellular Component:
centrosome; cytoplasm; cytoplasmic dynein complex; cytosol; dynein complex; microtubule; vesicle
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Molecular Function:
dynein heavy chain binding; dynein light chain binding; microtubule motor activity; protein binding
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Biological Process:
microtubule-based movement; transport along microtubule
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Reference #:
Q13409
(UniProtKB)
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Alt. Names/Synonyms: Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; DC1I2; DH IC-2; DIC74; DNCI2; DNCIC2; DYNC1I2; dynein cytoplasmic 1 intermediate chain 2; Dynein intermediate chain 2, cytosolic; dynein, cytoplasmic 1, intermediate chain 2; dynein, cytoplasmic, intermediate polypeptide 2; FLJ21089; FLJ90842; IC2; MGC104199; MGC111094; MGC9324; NEDMIBA; testis tissue sperm-binding protein Li 66n
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Gene Symbols: DYNC1I2
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Molecular weight:
71,457 Da
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Basal Isoelectric point:
5.08
Predict pI for various phosphorylation states
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