DYNC1I2 intermediate chain 2 of dynein. The intermediate chains seem to help dynein bind to dynactin 150 kDa component. The dynein complex is involved in microtubule motor activity and consists of at least two heavy chains and a number of intermediate and light chains. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component:  centrosome; cytoplasm; cytoplasmic dynein complex; cytosol; dynein complex; microtubule; vesicle
Molecular Function:  ATP-dependent microtubule motor activity, plus-end-directed; dynein heavy chain binding; dynein light chain binding; microtubule motor activity; protein binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; ER to Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; microtubule-based movement; positive regulation of ATP-dependent microtubule motor activity, plus-end-directed; regulation of G2/M transition of mitotic cell cycle; transport along microtubule; viral process
Reference #:  Q13409 (UniProtKB)
Alt. Names/Synonyms: Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; DC1I2; DH IC-2; DNCI2; DNCIC2; DYNC1I2; Dynein intermediate chain 2, cytosolic; dynein, cytoplasmic 1, intermediate chain 2; dynein, cytoplasmic, intermediate polypeptide 2; FLJ21089; FLJ90842; IC2; MGC104199; MGC111094; MGC9324
Gene Symbols: DYNC1I2
Molecular weight: 71,457 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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