DYNC1I2 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. Belongs to the dynein intermediate chain family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component:  centrosome; cytoplasm; cytosol; microtubule; vesicle
Molecular Function:  microtubule motor activity; protein binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; ciliary basal body-plasma membrane docking; ER to Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; microtubule-based movement; regulation of G2/M transition of mitotic cell cycle; viral process
Reference #:  Q13409 (UniProtKB)
Alt. Names/Synonyms: Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; DC1I2; DH IC-2; DNCI2; DNCIC2; DYNC1I2; Dynein intermediate chain 2, cytosolic; dynein, cytoplasmic 1, intermediate chain 2; dynein, cytoplasmic, intermediate polypeptide 2; FLJ21089; FLJ90842; IC2; MGC104199; MGC111094; MGC9324
Gene Symbols: DYNC1I2
Molecular weight: 71,457 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
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DYNC1I2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene