EIF4G2 Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. Belongs to the eukaryotic initiation factor 4G family. Ubiquitously expressed in all adult tissues examined, with high levels in skeletal muscle and heart. Also expressed in fetal brain, lung, liver and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation; Translation initiation
Chromosomal Location of human Ortholog: 11p15.4
Cellular Component:  cytosol; eukaryotic translation initiation factor 4F complex
Molecular Function:  mRNA binding; protein binding; translation factor activity, RNA binding; translation initiation factor activity
Biological Process:  cell death; cellular macromolecule biosynthetic process; negative regulation of autophagy; positive regulation of cell growth; regulation of cell cycle; regulation of translational initiation; translational initiation
Reference #:  P78344 (UniProtKB)
Alt. Names/Synonyms: AAG1; aging-associated protein 1; DAP-5; DAP5; Death-associated protein 5; eIF-4-gamma 2; eIF-4G 2; eIF4G 2; EIF4G2; Eukaryotic translation initiation factor 4 gamma 2; eukaryotic translation initiation factor 4 gamma, 2; eukaryotic translation initiation factor 4G-like 1; FLJ41344; IF4G2; NAT1; p97
Gene Symbols: EIF4G2
Molecular weight: 102,362 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EIF4G2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene