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EIF4G2
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. Belongs to the eukaryotic initiation factor 4G family. Ubiquitously expressed in all adult tissues examined, with high levels in skeletal muscle and heart. Also expressed in fetal brain, lung, liver and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding; Translation; Translation initiation |
| Chromosomal Location of human Ortholog: 11p15.4 |
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Cellular Component:
cytosol; eukaryotic translation initiation factor 4F complex
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Molecular Function:
mRNA binding; protein binding; translation factor activity, RNA binding; translation initiation factor activity
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Biological Process:
cell death; cellular macromolecule biosynthetic process; negative regulation of autophagy; positive regulation of cell growth; regulation of cell cycle; regulation of translational initiation; translational initiation
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Reference #:
P78344
(UniProtKB)
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Alt. Names/Synonyms: AAG1; aging-associated protein 1; DAP-5; DAP5; Death-associated protein 5; eIF-4-gamma 2; eIF-4G 2; eIF4G 2; EIF4G2; Eukaryotic translation initiation factor 4 gamma 2; eukaryotic translation initiation factor 4 gamma, 2; eukaryotic translation initiation factor 4G-like 1; FLJ41344; IF4G2; NAT1; p97
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Gene Symbols: EIF4G2
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Molecular weight:
102,362 Da
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Basal Isoelectric point:
6.7
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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