CTPS This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. Belongs to the CTP synthase family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 1p34.2
Cellular Component:  cytoophidium; cytosol
Molecular Function:  ATP binding; CTP synthase activity; identical protein binding
Biological Process:  'de novo' CTP biosynthetic process; B cell proliferation; CTP biosynthetic process; glutamine metabolic process; nucleobase-containing compound metabolic process; nucleobase-containing small molecule interconversion; response to drug; T cell proliferation
Disease: Immunodeficiency 24
Reference #:  P17812 (UniProtKB)
Alt. Names/Synonyms: CTP synthase; CTP synthase 1; CTP synthetase 1; CTPS; cytidine 5'-triphosphate synthetase; cytidine 5-prime triphosphate synthetase; PYRG1; UTP--ammonia ligase 1
Gene Symbols: CTPS1
Molecular weight: 66,690 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CTPS

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene